Non-Hormonal Prescription Option for Hot Flashes

Hot-Flashes1Hot flashes and its nocturnal cousin, night sweats, the highly descriptive street names for the vasomotor symptoms (VMS) experienced by as many as 80% of menopausal women, are the most common of all menopausal symptoms.

No consensus exists on the pathophysiology of menopausal VMS, although many hypotheses have been proposed. Hot flashes (HFs) are hypothesized to result from a dysregulation of the hypothalamic temperature-regulating mechanisms, triggered by a decline in estrogen levels.

Alterations in neurotransmitters such as serotonin and norepinephrine (NE) are thus likely to play a crucial role in menopausal VMS. Core body temperature (CBT) is regulated between an upper threshold for sweating and a lower threshold for shivering. Between these thresholds is a “thermoneutral” zone, within which major thermoregulatory responses (sweating and shivering) do not occur. Fine thermoregulatory adjustments within the thermoneutral zone are affected by variations in peripheral blood flow. According to this theory, heat dissipation responses of HFs (sweating and peripheral vasodilation) would be triggered if CBT were elevated such that the upper threshold was crossed.

Hormone therapy (HT) has been known to be efficacious for most women with VMS due to menopause. Current clinical guidelines for HT recommend using the lowest dose for the shortest duration to relieve symptoms and reach treatment goals. Dose, route of administration, and duration of use should be tailored to the needs of each woman, and periodic reassessment of symptoms is required to evaluate whether a change of treatment is necessary. However, VMS recur in approximately half of women after discontinuation of HT. Certain health risks may preclude the use of HT in some patients, and some menopausal women with VMS who would otherwise be suitable candidates for HT prefer not to initiate or continue such treatments for a variety of reasons, including concerns about potential side effects.

When hormone therapy is not suitable or if there is an unwillingness to take HT, or if a woman simply prefers a non-hormonal therapy, the prescription medication, BRISDELLE, offers women and practitioners an FDA-approved, non-hormonal pharmacologic treatment option for moderate to severe VMS due to menopause. BRISDELLE® (paroxetine) 7.5 mg is a low-dose selective serotonin reuptake inhibitor (SSRI) shown to be efficacious in treating moderate to severe VMS associated with menopause. This dose is lower than those used in treating psychiatric disorders. BRISDELLE is not indicated for depression or any other psychiatric condition. BRISDELLE’s efficacy, safety and tolerability were demonstrated in rigorous clinical trials specifically designed to treat moderate to severe hot flashes due to menopause

The median age of natural menopause is 51.3 years. Women of this age are no longer old and could expect to live an additional active 20 – 30 – 40 years with good health habits and proper medical care. There is no need to debilitate yourself by neglecting any condition for which there are suitable therapies available.

Talk to your doctor or health care professional about your options!

 

Interested in women’s sexual health? Contact us for an appointment.

Over-the-Counter Menopause RemediesThere’s a vast array of drugstore products available that claim to treat menopause symptoms. Many patients want to know if these products truly provide relief. While there are certainly over-the-counter products that work for mild hot flashes, night sweats or other menopause symptoms, few will work on severe or persistent symptoms.

As a general rule, I suggest being wary of “miracle cures” when you go to select a product. Since these herbal and nutritional products are not regulated by the U.S. Food and Drug Administration (FDA), they are seldom tested for efficacy or safety the way pharmaceuticals are. So there’s no way to know for certain that they contain the amount of active ingredients that they claim to have or if the benefit claims on the packaging are valid.

When exploring over-the-counter products, be an extremely savvy shopper. There’s no way to know whether the amount of active ingredients listed is incomplete or incorrect. The packaging could also tout benefits that are exaggerated since there’s no testing required by the FDA on these products.  It’s very hard to know exactly what you’re buying, so if you want to explore over-the-counter products, be an extremely savvy shopper.

Overall, it is important to talk to your healthcare provider before taking any unregulated over-the-counter product. Most importantly, discuss the following:

  • Does this herb or dietary supplement have possible side effects?
  • Will this product interact with any of my other medications or affect an unrelated medical condition?
  • What scientific evidence is there about how effective this remedy might be for my particular menopausal symptoms?
  • What are the risks of over-the-counter menopause treatments?

Remember, there’s no one-size-fits-all approach to treating menopause symptoms. What works for one woman may not for another. Talk to your doctor or ask your pharmacist to help you choose a product for easing mild menopausal symptoms that’s right for you.

 

Interested in women’s sexual health? Contact us for an appointment.

Recent Posts

Categories

Archives